Significance of the Hydroxyl Groups of Steroids in Promoting Growth
نویسندگان
چکیده
The presence of a 17beta-hydroxyl group endows the simple androstane molecule with the ability to produce growth of the uterus, vagina, and prostate of the female hypophysectomized albino rat. It appears that hydrogen atoms at position 17 are of critical importance since related compounds with a ketone group at this site are inactive. Monofunctional steroids with a hydroxyl or a ketone group at position 3 likewise are devoid of activity. If a phenolic A-ring is present in monofunctional steroids the 17beta-hydroxyl group is not obligatory for growth. Proliferation of the uterus and vagina were found to follow the administration of 17-desoxyestradiol.
منابع مشابه
Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy
Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of non-inhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties. Although the structural domains of the PEDF gene that mediate such diverse ef...
متن کاملThe Depression of Estrone-induced Uterine Growth by Phenolic Estrogens with Oxygenated Functions at Positions 6 or 16: the Impeded Estrogens
Two small groups of steroids in the estrane series-here designated as impeded estrogens,-represent a class of compounds which differ from the majority of estrogenic substances in exerting certain unusual influences on growth of the uterus. The induction of these effects previously was considered to be peculiar to estriol. The unusual growth properties common to impeded estrogens are twofold: (a...
متن کاملAntioxidative, Antihyperlipidemic, and Growth-Promoting Effects of Kelussia odoratissima in Meat-type Chickens
Due to the presence of polyphenols and phthalides in Kelussia odoratissima Mozzaf (Umbelliferae; K. odoratissima hereafter), this medicinal plant might be a robust in-feed additive to modulate lipid peroxidation in meat-type chickens. The present study evaluates antioxidative, antihyperlipidemic, and growth-promoting effects of K. odoratissima in meat-type chickens. In a 37-day trial (5-42 days...
متن کاملHealth-promoting Lifestyle and its Relationship with Examining Self-efficacy among Students of GONABAD University of Medical Sciences in 2019: a Descriptive Study
Introduction: Student life is one of the most crucial periods in terms of health-promoting behaviors. Given the significance of youth health in promoting the health of society and the fact that self-efficacy is a component of a healthy lifestyle, this study sought to evaluate the health-promoting lifestyle and self-efficacy of students at Gonabad University of Medical Sciences. Materials a...
متن کاملSulfuric acid ([3-(3-silicapropyl)-sulfanyl]propyl)ester as recyclable catalyst for the silylation of hydroxyl groups
Sulfuric acid ([3-(3-silicapropyl)sulfanyl]propyl]ester (SASPSPE) is employed as a recyclable catalyst for the silylation of hydroxyl groups. A good range of primary, secondary alcohols and phenolic hydroxyl groups were effectively converted into their corresponding trimethylsilyl ethers with hexamethyldisilazane in the presence of catalytic amounts of SASPSPE at room temperature with short rea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 100 شماره
صفحات -
تاریخ انتشار 1954